The bloody saga of Mexican and Colombian cartels following Pablo Escobar's death. It's 1994. Pablo Escobar has been killed, and the Colombian Medellin cartel has been dismantled: a short lived victory for the DEA. The Mexican cartels now see an opening to establish a new organized trade. Power shifts from Colombia and now centers on Mexico as the primary distributor of narcotics. "After Pablo" tells the story of the the Mexican and Colombian cartels in the time following Escobar's death. Each player controls a cartel and must establish leadership and control of the drug market while maintaining the business of his/her operations. After several seasons, the cartel which has taken the greatest command of the narco trade will gain the trust of the market and fill the gap left by Escobar's death. The Serpent has many heads.